Table 2.
Overall cellular and interstitial composition of the left ventricular myocardium in 12 control cats and 16 cats with hypertrophic cardiomyopathy (HCM).a
| Parameter | Control (n = 12) | HCM (n = 16) | P |
|---|---|---|---|
| CD31 (n/mm2)b | 2342.38 ± 417.11 | 1686.18 ± 241.4 | <.001 |
| Interstitium (edema)c | 0.38 ± 0.19 | 5.84 ± 3.96 | .002 |
| Interstitium (collagen)c | 1.22 ± 0.95 | 2.9 ± 1.9 | .012 |
| Ki67 (n/mm2)d | 1.32 ± 1.62 | 19.49 ± 19.79 | <.001 |
| Iba1 (n/mm2)d | 6.36 ± 3.80 | 64.48 ± 73.19 | <.001 |
| Calprotectin (n/mm2)d | 3.11 ± 3.10 | 16.21 ± 24.02 | .541 |
aThe data show the mean ± standard deviation based on the morphometric evaluation of histological and immunohistochemical specimens.
b Number of capillaries (n/mm2) based on the number of CD31-positive endothelial cells in 20 square regions of interest (ROI) of 0.09 mm2.
c Percentage of myocardium composed of interstitial edema or interstitial collagen (Van-Gieson stain: positive) in 20 square regions of interest (ROI) of 0.09 mm2.
d Number (n/mm2) of positive cells in an entire cross section of the left ventricular free wall (6 mm width).