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. Author manuscript; available in PMC: 2023 Feb 8.
Published in final edited form as: Biochemistry. 2021 Sep 2;62(3):588–600. doi: 10.1021/acs.biochem.1c00464

Figure 1. Targeted protein degradation with heterobifunctional PROTACs.

Figure 1.

PROTACs consist of a protein-targeting ligand linked to an E3 ubiquitin ligase recruiter via a linker to induce the proximity of an E3 ligase with a neo-substrate target protein to induce ubiquitination and proteasome-mediated degradation of the target protein.