Table 6. Apparent Thermodynamic Parameters for Dissolution Behavior of MET·HCl in Three Binary Solvents at T_hm.

	ΔG (kJ·mol–1)	ΔH (kJ·mol–1)	ΔS (J·K–1·mol–1)	TΔS (kJ·mol–1)	% ζH	% ζTS
Water + DMF
0.30	12.19	13.56	4.508	1.364	90.86	9.143
0.40	11.27	13.71	8.065	2.440	84.89	15.11
0.50	10.46	15.05	15.19	4.598	76.60	23.40
0.60	9.730	16.09	21.02	6.361	71.67	28.33
0.70	9.075	15.90	22.57	6.830	69.96	30.04
0.80	8.652	15.94	24.09	7.289	68.62	31.38
0.90	7.984	15.31	24.21	7.327	67.63	32.37
1.00	7.685	16.06	27.68	8.375	65.73	34.27
Water + Acetonitrile
0.30	13.19	14.33	3.739	1.131	92.68	7.319
0.40	11.34	16.09	15.71	4.753	77.20	22.80
0.50	10.17	19.74	31.64	9.575	67.34	32.66
0.60	9.182	15.47	20.78	6.288	71.10	28.90
0.70	8.499	14.71	20.53	6.212	70.31	29.69
0.80	8.195	15.27	23.38	7.076	68.34	31.66
0.90	7.732	15.59	25.96	7.856	66.49	33.51
1.00	7.685	16.06	27.68	8.375	65.73	34.27
Water + n-Propanol
0.30	12.92	25.24	40.71	12.32	67.20	32.80
0.40	11.53	22.82	37.29	11.28	66.91	33.09
0.50	10.42	22.42	39.65	12.00	65.14	34.86
0.60	9.550	21.14	38.32	11.59	64.58	35.42
0.70	8.829	19.51	35.30	10.68	64.62	35.38
0.80	8.453	18.98	34.79	10.53	64.32	35.68
0.90	7.845	18.02	33.63	10.18	63.91	36.09
1.00	7.685	16.06	27.68	8.375	65.73	34.27