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. 2022 Mar 17;22:109. doi: 10.1186/s12872-022-02539-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Endothelial function, vascular stiffness, and atherosclerotic plaque. Carotid intima media thickness (CIMT, a surrogate for atherosclerotic plaque burden), pulse wave velocity (PWV, a measure of vascular stiffness), and reactive hyperemia index (RHI, a measure of endothelial function) were similar in ApoB^R3500Q heterozygotes (gray squares) and controls (white circles) and did not correlate with LDL-C or age in either group. CIMT and RHI correlated with age in overall subjects. ApoB^R3500Q homozygotes (black triangles) were not included in statistical analysis due to small sample size but are presented for completeness. Imaging values association with LDL-C or age measured by Spearman’s rho (r_s)