TABLE 1.
Nikkomycin Z MICs and FICs for clinical fungal isolates
| Species (no. of isolates) | Nikkomycin Z MIC (μg/ml)
|
FIC of nikko-mycin Z with:
|
||
|---|---|---|---|---|
| Range | MIC50a | Flucon-azole | Itracon-azole | |
| C. albicans (15) | <0.5–32 | 4 | 0.48 | 0.2 |
| C. tropicalis (4) | >64 | >64 | >1 | >1 |
| C. krusei (4) | >64 | >64 | >1 | >1 |
| C. glabrata (3) | >64 | >64 | >1 | >1 |
| C. parapsilosis (4) | 1–4 | 2 | 0.32 | 0.46 |
| Cryptococcus neoformans (15) | <0.5–>64 | >64 | 0.72 | 0.49 |
| Scedosporium spp. (2) | >64 | >64 | >1 | >1 |
| Paecilomyces spp. (2) | >64 | >64 | >1 | 0.83 |
| Trichoderma spp. (2) | 64 | 64 | >1 | 0.71 |
| Penicillium spp. (2) | >64 | >64 | >1 | 0.83 |
| Fusarium spp. (2) | >64 | >64 | >1 | >1 |
| A. fumigatus (13) | >64 | >64 | >1 | 0.35 |
| A. flavus (13) | >64 | >64 | >1 | 0.33 |
| A. niger (7) | >64 | >64 | >1 | >1 |
| A. versicolor (1) | >64 | >64 | >1 | >1 |
| A. nidulans (1) | >64 | >64 | >1 | 0.52 |
| Coccidioides immitis (10) | 1–16 | 4 | 0.44 | 0.47 |
| E. jeanselmia (3) | >64 | >64 | >1 | >1 |
| E. spinifera (1) | >64 | >64 | >1 | NAc |
| Bipolaris spp. (2) | >64 | >64 | 0.64 | NA |
| W. dermatitidis (1) | >64 | >64 | >1 | 0.56 |
| O. humicola (1) | 4 | 4 | >1 | >1 |
| P. werneckii (1) | >64 | >64 | >1 | >1 |
| Cladophialophora bantiana (1) | >64 | >64 | >1 | >1 |
a
MIC50, MIC at which 50% of the isolates were inhibited.
b
FICs were based on the MIC80s for all isolates except those of C. albicans, C. parapsilosis, and Cryptococcus neoformans, for which MIC100s were used (Table 2).
c
NA, not applicable. Itraconazole MICs for these organisms were at the lowest concentration tested; therefore, the drug interaction could not be determined.