TABLE 2.
Summary of interactions between nikkomycin Z and fluconazole and itraconazole against clinical fungal isolates
| Species (no. of isolates) | FICa
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Nikkomycin Z + fluconazole
|
Nikkomycin Z + itraconazole
|
|||||||
| Synergistic | Additive | Indifferent | NAb | Synergistic | Additive | Indifferent | NA | |
| C. albicans (15) | 7 (9) | 2 (2) | 4 (4) | 2 (0) | 3 (13) | 5 (2) | 7 (0) | |
| C. tropicalis (4) | 1 | 3 | 1 | 3 | ||||
| C. krusei (4) | 4 | 4 | ||||||
| C. glabrata (3) | 1 | 2 | 1 | 2 | ||||
| C. parapsilosis (4) | 1 (4) | 3 (0) | 0 (3) | 3 (1) | 1 (0) | |||
| Cryptococcus neoformans (15) | 1 (6) | 3 (1) | 10 (8) | 1 (0) | 1 (8) | 3 (3) | 4 (4) | 7 (0) |
| Scedosporium spp. (2) | 2 | 2 | ||||||
| Paecilomyces spp. (2) | 2 | 1 | 1 | |||||
| Trichoderma spp. (2) | 2 | 1 | 1 | |||||
| Penicillium spp. (2) | 2 | 1 | 1 | |||||
| Fusarium spp. (2) | 2 | 2 | ||||||
| A. fumigatus (13) | 13 | 11 | 2 | |||||
| A. flavus (13) | 13 | 10 | 3 | |||||
| A. niger (7) | 7 | 7 | ||||||
| A. versicolor (1) | 1 | 1 | ||||||
| A. nidulans (1) | 1 | 1 | ||||||
| Coccidioides immitis (10) | 8 | 2 | 8 | 2 | ||||
| E. jeanselmia (3) | 1 | 2 | 3 | |||||
| E. spinifera (1) | 1 | 1 | ||||||
| Bipolaris spp. (2) | 1 | 1 | 2 | |||||
| W. dermatitidis (1) | 1 | 1 | ||||||
| O. humicola (1) | 1 | 1 | ||||||
| P. werneckii (1) | 1 | 1 | ||||||
| Cladophialophora bantiana (1) | 1 | 1 | ||||||
a
Drug interactions were based on MIC80s. Values in parentheses were based on MIC100s.
b
NA, not applicable. When the MIC for either drug used alone is lower than the lowest concentration tested, synergistic or additive interaction cannot be determined. For the same reason, FICs cannot be determined for these isolates.