Table 2.
Peri-tumoural monounsaturated, polyunsaturated and saturated fatty acids (MUFA, PUFA, SFA) mean, skewness, entropy and kurtosis were compared between molecular subtypes and in tubule formation Scores 2 and 3. The Spearman’s rank correlation coefficients (ρ) between lipid constituents against proliferative activity marker Ki-67 and tumour-infiltrating lymphocytes (TILs) are also shown. Statistical significant differences (p < 0.05) are marked by ‘*’
| Lipid | Spatial distribution measures | Molecular subtypes | Tubule formation | P | Ki-67 | TILs | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Luminal A (n = 9) | Luminal B-HER2(-) (n = 4) | Luminal B-HER( +) (n = 4) | Triple Negative (n = 3) | Score 2 (n = 9) | Score 3 (n = 11) | ρ | p | ρ | p | |||
| MUFA | Mean | 0.39 ± 0.02 | 0.39 ± 0.01 | 0.39 ± 0.01 | 0.39 ± 0.02 | 0.40 ± 0.01 | 0.38 ± 0.02 | 0.012* | -0.54 | 0.014* | -0.46 | 0.040* |
| Skewness | -1.80 ± 0.78 | -1.43 ± 0.63 | -1.77 ± 0.93 | -1.79 ± 1.08 | -2.17 ± 0.55 | -1.35 ± 0.75 | 0.012* | 0.60 | 0.005* | 0.42 | 0.066 | |
| Entropy | 4.71 ± 0.32 | 5.00 ± 0.18 | 4.81 ± 0.38 | 4.83 ± 0.38 | 4.62 ± 0.30 | 4.94 ± 0.24 | 0.022* | 0.67 | 0.001* | 0.32 | 0.169 | |
| Kurtosis | 8.64 (6.04 – 10.71) | 6.18 (4.46 – 7.82) | 7.08 (6.02 – 9.67) | 5.44 (4.86 – 11.01) | 8.91 (7.37 – 12.80) | 5.44 (4.08 – 7.21) | 0.038* | -0.44 | 0.054 | -0.40 | 0.080 | |
| PUFA | Mean | 0.12 ± 0.02 | 0.10 ± 0.01 | 0.11 ± 0.01 | 0.11 ± 0.03 | 0.12 ± 0.01 | 0.11 ± 0.02 | 0.099 | -0.56 | 0.010* | -0.33 | 0.161 |
| Skewness | 3.90 ± 0.83 | 3.91 ± 0.50 | 4.70 ± 0.92 | 4.60 ± 1.49 | 4.12 ± 1.04 | 4.20 ± 0.85 | 0.852 | 0.10 | 0.682 | 0.02 | 0.923 | |
| Entropy | 5.23 ± 0.39 | 5.15 ± 0.12 | 5.11 ± 0.28 | 5.26 ± 0.36 | 5.16 ± 0.25 | 5.22 ± 0.36 | 0.708 | -0.15 | 0.540 | -0.06 | 0.803 | |
| Kurtosis | 30.60 (26.46 – 32.11) | 36.77 (35.44 – 37.79) | 42.76 (38.92 – 53.52) | 32.58 (28.86 – 52.97) | 38.29 (31.42 – 49.45) | 32.58 (27.44 – 36.77) | 0.295 | 0.28 | 0.230 | -0.20 | 0.404 | |
| SFA | Mean | 0.49 ± 0.04 | 0.51 ± 0.03 | 0.50 ± 0.02 | 0.50 ± 0.05 | 0.48 ± 0.02 | 0.51 ± 0.04 | 0.033* | 0.59 | 0.006* | 0.37 | 0.107 |
| Skewness | -0.11 ± 0.68 | -0.17 ± 0.37 | -0.03 ± 0.59 | -0.16 ± 0.33 | 0.22 ± 0.53 | -0.39 ± 0.37 | 0.011* | -0.42 | 0.067 | -0.26 | 0.259 | |
| Entropy | 6.02 ± 0.37 | 6.08 ± 0.08 | 5.99 ± 0.32 | 6.10 ± 0.19 | 5.96 ± 0.21 | 6.10 ± 0.32 | 0.272 | 0.18 | 0.450 | 0.08 | 0.738 | |
| Kurtosis | 5.45 (4.34 – 5.75) | 4.90 (4.68 – 5.04) | 4.76 (4.08 – 6.39) | 4.78 (4.65 – 5.10) | 5.45 (4.95 – 6.43) | 4.78 (4.09 – 5.36) | 0.067 | -0.45 | 0.049* | -0.32 | 0.165 | |