Table 4.
Multivariable analysis of infections at the stage of AIDS1 stratified by transmission mode
| n = 8198 | n = 3113 | |||||
|---|---|---|---|---|---|---|
| MSM3 | HET4 | |||||
| n (%)† | aPR [95% CI]‡ | p-value | n (%)† | aPR [95% CI]‡ | p-value | |
| GISD2 | ||||||
| Low deprivation | 253 (11.4%) | 1 | 149 (16.5%) | 1 | ||
| Medium deprivation | 594 (11.5%) | 0.98 [0.85, 1.13] | 0.750 | 299 (16.2%) | 0.99 [0.82, 1.19] | 0.923 |
| High deprivation | 126 (15.6%) | 1.21 [0.98, 1.50] | 0.076 | 61 (16.8%) | 1.05 [0.79, 1.40] | 0.735 |
| Sex | ||||||
| Male | 973 (11.9%) | 1 | 195 (19.2%) | 1 | ||
| Female | (omitted) | 314 (15.0%) | 0.72 [0.60, 0.86] | < 0.001 | ||
| Approx. age (time of infection) | ||||||
| 15 to 19 | 4 (3.5%) | 0.26 [0.10, 0.89] | 0.007 | 4 (5.8%) | 0.40 [0.16, 1.02] | 0.056 |
| 20 to 29 | 350 (12.1%) | 0.94 [0.82, 1.07] | 0.369 | 201 (19.0%) | 1.31 [1.07, 1.60] | 0.008 |
| 30 to 39 | 320 (12.8%) | 1 | 155 (15.0%) | 1 | ||
| 40 to 49 | 218 (11.6%) | 0.89 [0.76, 1.05] | 0.185 | 90 (16.3%) | 1.00 [0.78, 1.27] | 0.975 |
| 50 to 59 | 66 (10.5%) | 0.80 [0.62, 1.03] | 0.082 | 46 (15.9%) | 0.95 [0.68, 1.33] | 0.761 |
| 60 to 69 | 15 (9.8%) | 0.74 [0.45, 1.22] | 0.243 | 12 (13.4%) | 0.78 [0.45, 1.35] | 0.371 |
| > 69 | 0 (0.0%) | (omitted) | 1 (4.6%) | 0.25 [0.04, 1.75] | 0.165 | |
| Region of origin | ||||||
| Western and Central Europe | 896 (12.0%) | 1 | 215 (17.5%) | 1 | ||
| Asia and the Pacific | 30 (14.9%) | 1.26 [0.90, 1.76] | 0.173 | 35 (26.3%) | 1.57 [1.16, 2.12] | 0.003 |
| Caribbean | 1 (3.7%) | 0.31 [0.05, 2.15] | 0.238 | 3 (15.8%) | 0.90 [0.33, 2.49] | 0.846 |
| Eastern Europe and Central Asia | 13 (12.6%) | 1.05 [0.64, 1.71] | 0.849 | 26 (15.3%) | 0.90 [0.62, 1.31] | 0.596 |
| Latin America | 15 (7.0%) | 0.62 [0.38, 1.02] | 0.059 | 5 (19.2%) | 1.03 [0.47, 2.29] | 0.935 |
| Middle East and North Africa | 5 (5.3%) | 0.44 [0.19, 1.02] | 0.057 | 11 (14.1%) | 0.71 [0.38, 1.32] | 0.278 |
| North America | 4 (9.8%) | 0.88 [0.36, 2.17] | 0.789 | 1 (25.0%) | 1.45 [0.23, 9.01] | 0.692 |
| Sub-Saharan Africa | 9 (12.9%) | 1.08 [0.58, 2.01] | 0.798 | 213 (14.7%) | 0.79 [0.66, 0.95] | 0.014 |
| City size | ||||||
| Countryside < 100 k residents | 426 (14.1%) | 1.37 [1.16, 1.64] | < 0.001 | 253 (16.1%) | 0.90 [0.73, 1.11] | 0.333 |
| Town 100 k—< 1 million residents | 287 (11.4%) | 1.13 [0.94, 1.35] | 0.192 | 150 (16.2%) | 0.94 [0.75, 1.17] | 0.568 |
| Major city > = 1 million residents | 260 (9.9%) | 1 | 106 (17.4%) | 1 | ||
1AIDS Evidence of AIDS-defining illness, 2GISD German Index of Socioeconomic Deprivation, 3MSM Men who have sex with men, 4HET Persons with heterosexual contact
†Strata specific number and proportion of infections at the stage of AIDS at the time of diagnosis
‡Prevalence ratios with corresponding 95% confidence intervals of infections at the stage of AIDS at the time of diagnosis were calculated for the exposure variable GISD using stratified multivariable Poisson regression with ZIP code cluster-robust error variance (standard errors were adjusted for 644 clusters in the MSM stratum and 592 clusters in the HET stratum). The models were adjusted for the variables of sex, approximated age at the time of infection, region of origin and city size