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. 2022 Mar 16;22:124. doi: 10.1186/s12876-022-02186-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Receiver operating characteristic (ROC) curves of serum ceruloplasmin for the diagnosis of Wilson’ disease (WD). A When analyzing WD patients together with heterozygotes and non-WD patients, the area under the curve (AUC) was 0.990 (95% confidence interval (CI), 0.985–0.995). B When analyzing WD patients with acute liver failure and non-WD patients with acute liver failure, the area under the curve was 0.952 (95% confidence interval (CI), 0.885–1). C When analyzing asymptomatic WD patients and non-WD patients with viral hepatitis, the area under the curve was 0.994 (95% confidence interval (CI), 0.988–1). D–F Box and whisker plots show the values of serum ceruloplasmin in all WD and non-WD patients (D), the patients with acute liver failure and the patients (E) with elevated aminotransferases (F). The black line represents the consensus cutoff of serum ceruloplasmin (20 mg/dL). The dash lines in D–F represent the cutoff values obtained in the ROC curves of A–C (16.9 mg/dL, 16.0 mg/dL and 16.9 mg/dL), respectively.