Table 1.
Serum ceruloplasmin levels in healthy children and WD patients stratified by age
Age group | Healthy children | WD patients | p value | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cp(mg/dL) | Number | 0–5 | 5–10 | 10–15 | 15–20 | ≥ 20 | Cp(mg/dL) | Number | 0–5 | 5–10 | 10–15 | 15–10 | ≥ 20 | ||
< 6 mths | 25.5 ± 10.1 | 20 | 0 | 1 | 3 | 2 | 14 | – | – | – | – | – | – | – | – |
6 mths- | 33.0 ± 9.3 | 20 | 0 | 0 | 1 | 2 | 17 | 4.0 | 1 | 1 | 0 | 0 | 0 | 0 | – |
1 yr- | 31.5 ± 8.0 | 28 | 0 | 0 | 0 | 3 | 25 | 3.3 ± 2.2 | 4 | 3 | 1 | 0 | 0 | 0 | p < 0.001 |
2 yrs- | 30.0 ± 8.3 | 22 | 0 | 1 | 1 | 0 | 20 | 4.6 ± 3.3 | 19 | 13 | 5 | 0 | 1 | 0 | p < 0.001 |
3 yrs- | 32.0 ± 6.4 | 24 | 0 | 0 | 0 | 1 | 23 | 5.2 ± 5.1 | 51 | 33 | 12 | 3 | 0 | 3 | p < 0.001 |
4 yrs- | 33.7 ± 6.5 | 25 | 0 | 0 | 0 | 0 | 25 | 5.6 ± 4.4 | 59 | 35 | 15 | 5 | 3 | 1 | p < 0.001 |
5 yrs- | 31.7 ± 5.7 | 35 | 0 | 0 | 0 | 1 | 34 | 6.5 ± 5.6 | 48 | 25 | 12 | 8 | 1 | 2 | p < 0.001 |
6 yrs- | 33.7 ± 5.0 | 26 | 0 | 0 | 0 | 0 | 26 | 6.3 ± 5.1 | 38 | 20 | 10 | 5 | 3 | 0 | p < 0.001 |
7 yrs- | 31.6 ± 5.3 | 25 | 0 | 0 | 0 | 0 | 25 | 5.3 ± 3.7 | 25 | 16 | 4 | 5 | 0 | 0 | p < 0.001 |
8 yrs- | 30.9 ± 5.9 | 27 | 0 | 0 | 0 | 1 | 26 | 6.2 ± 4.8 | 20 | 10 | 6 | 2 | 2 | 0 | p < 0.001 |
9 yrs- | 28.9 ± 6.3 | 22 | 0 | 0 | 0 | 2 | 20 | 7.6 ± 5.2 | 8 | 3 | 3 | 1 | 1 | 0 | p < 0.001 |
10 yrs- | 29.1 ± 9.8 | 21 | 0 | 0 | 3 | 2 | 16 | 6.5 ± 4.5 | 17 | 9 | 4 | 2 | 2 | 0 | p < 0.001 |
11 yrs- | 27.5 ± 7.7 | 23 | 0 | 1 | 1 | 0 | 21 | 6.3 ± 3.2 | 9 | 4 | 3 | 2 | 0 | 0 | p < 0.001 |
12 yrs- | 32.4 ± 8.8 | 25 | 0 | 0 | 0 | 0 | 25 | 4.9 ± 3.2 | 13 | 9 | 2 | 2 | 0 | 0 | p < 0.001 |
13 yrs- | 26.3 ± 6.2 | 16 | 0 | 0 | 0 | 1 | 15 | 6.4 ± 4.3 | 3 | 1 | 1 | 1 | 0 | 0 | p < 0.001 |
14 yrs- | 29.1 ± 9.7 | 13 | 0 | 0 | 1 | 2 | 10 | 3.0 ± 1.0 | 2 | 2 | 0 | 0 | 0 | 0 | p = 0.003 |
Total | 30.7 ± 7.8 | 372 | 0 | 3 | 10 | 17 | 342 | 5.7 ± 4.7 | 317 | 184 | 78 | 36 | 13 | 6 | p < 0.001 |
Cp, ceruloplasmin; 0–5, 5–10, 10–15, 15–20 and ≥ 20 represented the ranges of serum ceruloplasmin (mg/dL); Number represented the number of the children with specific range of serum ceruloplasmin