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. 2022 Mar 16;22:124. doi: 10.1186/s12876-022-02186-0

Table 1.

Serum ceruloplasmin levels in healthy children and WD patients stratified by age

Age group Healthy children WD patients p value
Cp(mg/dL) Number 0–5 5–10 10–15 15–20 ≥ 20 Cp(mg/dL) Number 0–5 5–10 10–15 15–10 ≥ 20
 < 6 mths 25.5 ± 10.1 20 0 1 3 2 14
6 mths- 33.0 ± 9.3 20 0 0 1 2 17 4.0 1 1 0 0 0 0
1 yr- 31.5 ± 8.0 28 0 0 0 3 25 3.3 ± 2.2 4 3 1 0 0 0 p < 0.001
2 yrs- 30.0 ± 8.3 22 0 1 1 0 20 4.6 ± 3.3 19 13 5 0 1 0 p < 0.001
3 yrs- 32.0 ± 6.4 24 0 0 0 1 23 5.2 ± 5.1 51 33 12 3 0 3 p < 0.001
4 yrs- 33.7 ± 6.5 25 0 0 0 0 25 5.6 ± 4.4 59 35 15 5 3 1 p < 0.001
5 yrs- 31.7 ± 5.7 35 0 0 0 1 34 6.5 ± 5.6 48 25 12 8 1 2 p < 0.001
6 yrs- 33.7 ± 5.0 26 0 0 0 0 26 6.3 ± 5.1 38 20 10 5 3 0 p < 0.001
7 yrs- 31.6 ± 5.3 25 0 0 0 0 25 5.3 ± 3.7 25 16 4 5 0 0 p < 0.001
8 yrs- 30.9 ± 5.9 27 0 0 0 1 26 6.2 ± 4.8 20 10 6 2 2 0 p < 0.001
9 yrs- 28.9 ± 6.3 22 0 0 0 2 20 7.6 ± 5.2 8 3 3 1 1 0 p < 0.001
10 yrs- 29.1 ± 9.8 21 0 0 3 2 16 6.5 ± 4.5 17 9 4 2 2 0 p < 0.001
11 yrs- 27.5 ± 7.7 23 0 1 1 0 21 6.3 ± 3.2 9 4 3 2 0 0 p < 0.001
12 yrs- 32.4 ± 8.8 25 0 0 0 0 25 4.9 ± 3.2 13 9 2 2 0 0 p < 0.001
13 yrs- 26.3 ± 6.2 16 0 0 0 1 15 6.4 ± 4.3 3 1 1 1 0 0 p < 0.001
14 yrs- 29.1 ± 9.7 13 0 0 1 2 10 3.0 ± 1.0 2 2 0 0 0 0 p = 0.003
Total 30.7 ± 7.8 372 0 3 10 17 342 5.7 ± 4.7 317 184 78 36 13 6 p < 0.001

Cp, ceruloplasmin; 0–5, 5–10, 10–15, 15–20 and ≥ 20 represented the ranges of serum ceruloplasmin (mg/dL); Number represented the number of the children with specific range of serum ceruloplasmin