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. 2022 Mar 17;29:19. doi: 10.1186/s12929-022-00802-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A comparison between sORF and altORF transcripts in terms of length and initiation codons. A sORF transcript structure with AUG or non-AUG initiation codons, characterised by its short length of 100 codons after post-transcriptional modifications. B altORF transcript structure described with AUG initiation codon, longer than 30 codons and without an upper limit on length, differing from sORFs