FIG. 1.

Cumulative survival rates of treated and control mice challenged with 10⁸ CFU of A. baumannii SAN-94040 (a and b) or RCH-69 (c and d) per mouse. The treatment was initiated 8 h after intratracheal bacterial inoculation (five i.p. doses of β-lactams and one i.p. dose of rifampin). Symbols for monotherapy (a and c): ●, controls; ○, imipenem; □, sulbactam; ▵, ticarcillin; ▴, ticarcillin-clavulanate; ■, rifampin. Symbols for combinations (b and d): ○, rifampin-imipenem; □, rifampin-sulbactam; ▴, imipenem-sulbactam; ▵, ticarcillin-sulbactam; ▴, ticarcillin-clavulanate (25/1 ratio)-sulbactam; ■, rifampin-ticarcillin-clavulanate (25/1 ratio)-sulbactam. The number of mice in each group is indicated in parentheses.