TABLE 3.
Treatment of experimental pneumonia caused by A. baumannii SAN-94040 or RCH-69 with four doses of β-lactams and one dose of rifampin administered alone or in various combinations
| Treatment group (mg/kg)b | Log CFU/g of lung (mean ± SD)a
|
|
|---|---|---|
| SAN-94040 | RCH-69 | |
| Imipenem (50) | 4.47 ± 0.44c | 4.4 ± 1.1c |
| Sulbactam (100) | 4.31 ± 0.19c | 6.4 ± 1.3 |
| Ticarcillin (500) | 6.70 ± 0.68 | NDd |
| Ticarcillin (500)-clavulanate (25/1 ratio) | 5.79 ± 0.25c | ND |
| Rifampin (25) | 5.02 ± 0.45c | 3.3 ± 0.46c |
| Rifampin (25)-imipenem (50) | 4.3 ± 0.53c | 3.72 ± 0.29c |
| Rifampin (25)-sulbactam (100) | 5.03 ± 0.95c | 4.24 ± 1.1c |
| Imipenem (50)-sulbactam (100) | ND | 4.43 ± 0.7c |
| Ticarcillin (500)-sulbactam (100) | 5.4 ± 0.59c | ND |
| Ticarcillin (500)-clavulanate (25/1 ratio)-sulbactam (100) | 4.25 ± 0.29c | 6.3 ± 0.8 |
| Rifampin (25)-ticarcillin (500)-clavulanate (25/1 ratio)-sulbactam (100) | 5.35 ± 0.87c | 2.55 ± 0.4c |
a
Bacterial counts were determined 12 h after the first antibiotic dose. Values for controls were 7.6 ± 0.49 log CFU of SAN-94040 and 7.25 ± 0.71 log CFU of RCH-69 per g of lung tissue.
b
β-Lactams were administered every 3 h, and rifampin was given as a single dose.
c
P < 0.05 versus control.
d
ND, not determined.