Table 1.
Details of nine case reports compared to our case of SARS-CoV-2 associated MOG antibody optic neuritis.
| Author | Age | Sex | Underlying illness | Onset after COVID-19 symptoms | COVID-19 symptoms | Onset of optic neuritis | Laterality | Presenting visual acuity | CSF SARS-CoV-2 PCR | Treatment | Final visual acuity after admission |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Zhou1 | 26 | M | none | a few D | dry cough | 3 D | OD > OS | OD HM OS 20/250 | Negative | IVMP 5D followed by oral steroid | OU 20/50 at D 7 OU 20/30 at W 3 |
| Sawalha2 | 44 | M | none | 2 W | shortness of breath and cough | 1 W | OD > OS | OD 20/200 OS 20/30 | NA | IVMP 5D followed by oral steroid | NA (significant improvement) |
| Khan3 | 11 | M | none | 2 W | a brief febrile illness and redness of both eyes | 1-2 D | OD > OS | OD PJ OS 20/30 | NA | IVMP 5D followed by oral steroid | OD 20/30 at D 10 OS 20/20 at D 10 |
| Kogure4 | 47 | M | post adrenal resection due to hyperaldosteronism, recurrent paranasal sinusitis | detected during admission | asymptomatic | NA | OS | OD NA OS 20/400 | Negative | IVMP 3D followed by oral steroid | OS 20/200 at D 10 OS 20/16 at W 2 |
| Zoric5 | 63 | M | hypertension, diabetes mellitus | 4 W | pneumonia CXR resolved before onset of optic neuritis | 1 W | OD | OD 20/630 OS 20/20 | NA | IVMP 5D followed by oral steroid | OD 20/63 at D 5 OD 20/25 at W 3 |
| Woodhall6 | 39 | F | MOG antibody optic neuritis (remission) | 6 D | malaise, coryzal symptoms, sweating. | NA | OD | OD HM OS 20/20 | NA | IVMP 5D followed by plasma exchange | OD 20/125 at W 2 |
| Rojas-Correa7 | 69 | M | diabetes mellitus | 45 D | fever, rhinorrhoea, cough | NA (subacute) | OD > OS | OD 20/60 OS 20/30 | Negative | IVMP 5D | OD 20/30 at D 5 OS 20/25 at D 5 |
| de Ruijter8 | 15 | M | none | 2–3 W | fever, nausea, and a cough | 7 D | OD > OS | OD 1/300 OS 1/70 | NA | IVMP 3D | NA (almost fully improvement) |
| Jossy9 | 38 | M | none | 2 W and recurrent at 6 W | NA (mild symptom, home isolation) | 5 D (2nd episode) | OS | OD 20/20 OS HM (2nd episode) | NA | IVMP followed by oral steroid for 1st episode; IVMP 3D followed by oral prednisolone as per ONTT protocol for 2nd episode | OS 20/20 at D 7 (2nd episode) |
| Our case | 35 | F | none | 1 W | dry cough | 6 D | OS > OD | OD 20/32 OS FC 2 ft | Negative | IVMP 5D followed by oral steroid | OU 20/30 at D 8 OD 20/25 at W 4 OS 20/20 at W 4 |
Abbreviation: M male, F female, CXR chest X-ray, D day, W week, OD right eye, OS left eye, OU both eye, PJ light projection, HM hand motion, FC finger count, Ft feet, CSF cerebrospinal fluid, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, COVID-19 Coronavirus disease 2019, PCR polymerase chain reaction, IVMP intravenous methylprednisolone, NA not available.