Searches – 16/4/12 Ovid MEDLINE(R) In‐Process & Other Non‐Indexed Citations and Ovid MEDLINE(R) 1946 to Present
1	exp Vascular Surgical Procedures/ or exp/amputation
2	exp Peripheral Vascular Diseases/su, th or exp aortic aneurysm, abdominal/su, th or exp aortic aneurysm, thoracic/su, th or exp aortic rupture/su, th or exp Carotid Stenosis/su, th or exp Atherosclerosis/su, th or exp Intermittent Claudication/su, th or ((exp Aorta, Abdominal/ or exp Aorta, Thoracic/) and surg*.ti,ab.)
3	((abdominal or thoracic or thoracoabdominal) adj3 aneurysm*).mp.
4	(((iliac* adj3 arter*) or infrainguinal or (femoropop* or femoro‐pop*) or (vascular or AAA or aort* or aneurysm* or carotid)) adj3 (endovascular or bypass or graft* or surg* or revasc*or repair* or procedur* or operat*)).mp.
5	(endarterectomy or peripheral revasculari#ation or lower extremity revasculari#ation or critical limb ischaemia or critical limb ischemia).mp.
6	(interm* adj3 claud*).mp.
7	amputation*.ti,ab.
8	or/1‐7
9	(statin* or simvastatin or rosuvastatin or fluvastatin or cerivastatin or lovastatin or pravastatin or atorvastatin).af.
10	(lipitor or lescol or lipostat or crestor or zocor).af.
11	exp Hydroxymethylglutaryl‐CoA‐Reductase Inhibitors/
12	or/9‐11
13	((randomized controlled trial or controlled clinical trial).pt. or randomi#ed.ab. or placebo.ab. or drug therapy.fs. or randomly.ab. or trial.ab. or groups.ab.) not (animals not (humans and animals)).sh.
14	8 and 12 and 13
	Searches – 16/4/12 Embase 1974 to 2012 April 03++++++++
1	placebo.sh. or controlled study.ab. or random*.ti,ab. or trial*.ti,ab.
2	((singl* or doubl* or trebl* or tripl*) adj3 (blind* or mask*)).ti,ab.
3	1 or 2
4	(animals not (humans and animals)).sh.
5	3 not 4
6	exp hydroxymethylglutaryl coenzyme A reductase inhibitor/
7	(statin* or simvastatin or rosuvastatin or fluvastatin or cerivastatin or lovastatin or pravastatin or atorvastatin).af.
8	(lipitor or lescol or lipostat or crestor or zocor).af.
9	6 or 7 or 8
10	exp vascular surgery/ or exp limb amputation/
11	exp peripheral vascular disease/su, th or exp carotid artery obstruction/su, th or exp carotid atherosclerosis/su, th or exp peripheral occlusive artery disease/su, th or exp atherosclerosis/su, th or ((exp abdominal aorta/ or exp thoracic aorta/) and surg*.ti,ab.) or exp aorta aneurysm/su, th or exp aorta atherosclerosis/su, th or exp aorta occlusion/su, th or exp aorta rupture/su, th
12	((abdominal or thoracic or thoracoabdominal) adj3 aneurysm*).mp.
13	(((iliac* adj3 arter*) or infrainguinal or (femoropop* or femoro‐pop*) or (vascular or aort* or AAA or aneurysm* or carotid)) adj3 (endovascular or bypass or graft* or surg* or revasc*or repair* or procedur* or operat*)).mp.
14	(endarterectomy or peripheral revasculari#ation or lower extremity revasculari#ation or critical limb ischaemia or critical limb ischemia).mp.
15	(interm* adj3 claud*).mp.
16	amputation*.ti,ab.
17	or/10‐16
18	5 and 9 and 17
19	exp in vitro study/
20	exp animal experiment/
21	exp animal model/
22	exp nonhuman/
23	exp animals/
24	exp human/
25	or/19‐23
26	25 not 24
27	18 and 26
28	18 not 26
	CENTRAL 16/3/12
ID	Search
#1	MeSH descriptor Vascular Surgical Procedures explode all trees
#2	MeSH descriptor Hydroxymethylglutaryl‐CoA Reductase Inhibitors explode all trees
#3	statin* OR simvastatin OR rosuvastatin OR fluvastatin OR cerivastatin OR lovastatin OR pravastatin OR atorvastatin in Clinical Trials
#4	lipitor OR lescol OR lipostat OR crestor OR zocor in Clinical Trials
#5	(#2 OR #3 OR #4)
#6	MeSH descriptor Peripheral Vascular Diseases explode all trees with qualifiers: SU,TH
#7	MeSH descriptor Aortic Aneurysm, Abdominal explode all trees with qualifiers: SU,TH
#8	MeSH descriptor Aortic Aneurysm, Thoracic explode all trees with qualifiers: TH,SU
#9	MeSH descriptor Aortic Rupture explode all trees with qualifiers: SU,TH
#10	MeSH descriptor Carotid Stenosis explode all trees with qualifiers: TH,SU
#11	MeSH descriptor Atherosclerosis explode all trees with qualifiers: TH,SU
#12	MeSH descriptor Intermittent Claudication explode all trees with qualifiers: TH,SU
#13	MeSH descriptor Aorta, Abdominal explode all trees with qualifiers: TH,SU
#14	MeSH descriptor Aorta, Thoracic explode all trees with qualifiers: TH,SU
#15	surger*:ti,ab in Clinical Trials
#16	(( #13 OR #14 ) AND #15)
#17	(#6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #16)
#18	MeSH descriptor Amputation explode all trees
#19	(((vascular or aort* or aneurysm or carotid) near/3 (repair or procedur* or surg* or operat*)) or ((abdominal or thoracic or thoracoabdominal or endovascular) near/3 aneurysm*) or( (femoropop* or femoro‐pop*) near/3 (bypass or graft or surg*)) or (iliac* near/3 arter* near/3 (bypass or graft or surg*)) or (carotid endarterectomy or peripheral revascularisation or infrainguinal bypass) or (interm* near/3 claud*))
#20	(amputation):ti,ab,kw
#21	(#1 OR #17 OR #18 OR #19 OR #20)
#22	(#5 AND #21)