APVS study.

Methods	Atorvastatin in the Perioperative of Vascular Surgery (APVS) study. Single‐centre randomized controlled trial.
Participants	106 participants undergoing vascular surgery (aortic aneurysm, carotid endarterectomy and lower limb arterial surgery) in University Hospital, Brazil. Statin naive. Mean age, 69.6 years in A20 group and 65.8 years in A80 group.
Interventions	High‐dose (80 mg/day) atorvastatin (A80) compared with 20 mg/day atorvastatin (A20). 53 participants in each group, received drug for 60 days.
Outcomes	Follow‐up for 30 days after surgery. Primary endpoint: composite of cardiac death, non‐fatal myocardial infarction and stroke. 3 events in A80 group and 7 events in A20 group. Secondary endpoint: reduction in total and low‐density cholesterol CRP. Safety monitored via hepatic enzymes and creatinine kinase.
Funding sources	No statement about funding sources.
Duration of statin use before surgery	33 days average between randomization and surgery in both groups.
Notes	Study reported in two conference abstracts only. Emailed for further information 20/8/12 and 27/9/12.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Patients were randomly assigned". No further details.
Allocation concealment (selection bias)	Unclear risk	No details given.
Blinding of participants and personnel (performance bias) Mortality /complications	Low risk	Study described as "double‐blind".
Blinding of outcome assessment (detection bias) Mortality/complications	Unclear risk	Criteria and assessment process not described.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No details of losses to follow‐up.
Selective reporting (reporting bias)	Unclear risk	Premiminary reports only. Combined endpoint only reported.
Other bias	Unclear risk	Insufficient information to assess other potential risks of bias.