Ramo 1995.

Methods	Single‐centre randomized controlled trial.
Participants	37 participants undergoing percutaneous transluminal angioplasty (PTA) below inguinal ligament for critical ischaemia or severe claudication (< 20 m). University Hospital, Helsinki, Finland. Not stated that statin naive. Mean age, 68 years 45% female.
Interventions	Intervention (N = 18): 20 mg/day lovastatin plus 250 mg aspirin/day. Commenced on referral and angiogram usually within 2 days. Assume continued for 1 year. Control (N = 19) had aspirin only.
Outcomes	Participants followed up for 1 year. Outcomes reported repeated PTA (4/18 statin and 8/19 control), time to repeat PTA, amputation (2/18 statin users and 4/19 control).
Funding sources	No statement about funding sources.
Duration of statin use before surgery	2 days on average.
Notes	Authors emailed for further information 20/8/12 and 27/9/12.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"All patients were randomized into two groups". No further details given.
Allocation concealment (selection bias)	Unclear risk	No details given.
Blinding of participants and personnel (performance bias) Mortality /complications	High risk	No mention of blinding and no placebo given.
Blinding of outcome assessment (detection bias) Mortality/complications	High risk	"Angiograms were evaluated by two experienced interventional radiologists independently and without knowing the treatment patients were receiving". But angiograms during 1‐year follow‐up initiated by clinical staff who were aware of allocation.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants completed follow‐up.
Selective reporting (reporting bias)	Low risk	Study objective was to study restenosis only.
Other bias	Low risk	Statin group had worse clinical condition and fewer run‐off vessels at baseline. Therefore, reduced restenosis rate may be under‐estimate.