Vita 2012.

Trial name or title	Clinical Utility of Endothelial Dysfunction in PAD.
Methods	Randomized controlled trial.
Participants	Male and female participants aged 21 to 99 years old. Peripheral arterial disease: PAD is defined clinically and by angiography, magnetic resonance imaging, vascular ultrasound or ankle brachial index less than 0.9. Able to provide informed consent and complete the study procedure. Participants undergoing non‐emergent vascular surgery (peripheral arterial bypass, abdominal aortic aneurysm repair, carotid endarterectomy or limb amputation) or other noncardiac surgery.
Interventions	Atorvastatin. Ascorbic acid. Placebo.
Outcomes	Primary outcome measures: Brachial artery flow‐mediated dilation. Secondary outcome measures: Pulse wave velocity; and Markers of inflammation.
Starting date	May 2004. Estimated study completion date June 2012.
Contact information	Joseph A. Vita, Professor of Medicine, Boston University.
Notes	NCT00491751.

MI = Myocardial infarction; PAD = Peripheral arterial disease; VTE = Venous thromboembolism.