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. 2022 Mar 14;29(1):889–905. doi: 10.1080/10717544.2022.2050845

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — In vitro anti-tumor ability of (DTXL + siRNA)@NPs-ALN. (A) Calcein AM and PI staining of PC-3 cells for live and dead cell visualization. (B) cell viability of PC-3 cells treated with different formulation of DTXL and siRNA. (C) Western blotting analysis of relevant protein associated with apoptosis, proliferation and autophagy. (D) Cell cycle and apoptosis analysis after cells incubation with different formulation of DTXL and siRNA. The (DTXL + siRNA)@NPs-ALN group can induce cell apoptosis and cell cycle arrest at G2/M phase. (E) The proportions of G2/M phase cells and the proportion of early apoptosis (EA), the late apoptosis (LA) and total apoptosis (TA) are the most in the (DTXL + siRNA)@NPs-ALN group. Data were expressed as the mean ± SD (n = 3). *p < .05, **p < .01.