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. 2022 Mar 14;29(1):889–905. doi: 10.1080/10717544.2022.2050845

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Anti-cancer activity of (DTXL + siRNA)@NPs-ALN for mice prostate cancer bone metastasis. (A) the time points for establishment of prostate cancer bone metastasis and treatment. (B) the microCT images, HE image of bone metastasis treated with different groups, and the Ki-67 expression level and tumor cell apoptosis were also evaluated using immunohistochemistry and TUNEL staining. (C) tibia trabecular thickness and bone density (D) were also evaluated, and the tumor volume was also evaluated when mice were sacrificed (E). Data were expressed as the mean ± SD (n = 6). *p < .05.