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. 2021 Jul 2;18(1):1908030. doi: 10.1080/21645515.2021.1908030

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© 2021 Fred Hutchinson Cancer Research Center. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Plots of observed vs. predicted serum neutralization titer for each approach among double positives [category (4) samples]. (a) ID50, (b) ID80. Values in the lower right-hand corner of each plot correspond to CCCrm agreement values, with 95% confidence intervals shown in parentheses. Double positive = participant with detectable (>LLoQ) serum concentration of VRC01 and detectable (>LLoQ) serum VRC01-mediated neutralization. Breakthrough virus geometric mean: predict the geometric mean titer based on the geometric mean of the observed titers across the 4 breakthrough viruses, and the geometric mean of the IC50 values (Panel A) or of the IC80 values (Panel B) of the 4 breakthrough viruses (as if the geometric mean corresponded to a single virus).