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. 2022 Mar 14;13(1):569–577. doi: 10.1080/21505594.2022.2047506

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — A heat map showing the levels of activated Tfh cells (Cd4+cxcr5+icos+foxp3-), resting Tfh (Cd4+cxcr5+icos-Foxp3-), and Tfr cells (Cd4+cxcr5+icos+foxp3+) in relation with clinical and laboratory findings in COVID-19 patients. as shown, most of the CD4+CXCR5+ Tfh cells were activated (Icos+) in severe cases and the increase in its level was associated with higher LDH, D-dimer, and ferritin, as well as respiratory rate, and lower PaCo₂. Resting Tfh and Tfr cells showed opposite relations with the laboratory indices of severity.