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Imputed HLA haplotype and genotype frequencies for patients in pedigrees. HLA alleles were imputed using SNP2HLA software and Type 1 Diabetes Genome Consortium reference panel and then combined into HLA haplotypes and genotypes. A: A majority of haplotypes were high T1D risk DRB1*0301-DQA1*0501-DQB1*0201 (DR3) or DR4 haplotypes. B: Moreover, >80% of individuals had either one or two DR4 haplotypes, which further highlights the homogenic genetic risk for T1D in this cohort.
