Table 2.
Clinical characteristics of affected and unaffected individuals in pedigrees
| Affected (n = 255) | Unaffected (n = 128) | P | |
|---|---|---|---|
| Women, % | 40.4 | 52.3 | <0.0001 |
| Age, years | 59.5 ± 11.9 | 57.3 ± 11.0 | NS |
| BMI, kg/m2 | 26.4 ± 4.6 | 25.8 ± 3.8 | NS |
| Age at diabetes onset, years | 12.2 ± 7.5 | 16.0 ± 9.7 | <0.004 |
| Diabetes duration, years | 36.9 ± 10.8 | 30.5 ± 11.4 | <0.0001 |
| HbA1c, % | 8.74 ± 1.67 | 8.23 ± 1.23 | <0.05 |
| Systolic BP, mmHg | 142 ± 21 | 131 ± 17 | <0.0001 |
| Diastolic BP, mmHg | 81 ± 12 | 77 ± 8 | <0.05 |
| Median (IQR) AER, mg | 7.99 (4.56–11.955) | 157.29 (39.2–955) | <0.0001 |
| eGFR, mL/min per 1.73 m2 | 51 ± 19 | 97 ± 20 | <0.0001 |
| Microalbuminuria, n | 78 | — | — |
| Macroalbuminuria, n | 85 | — | — |
| ESRD, n | 92 | — | — |
Data presented as mean ± SD unless otherwise indicated. BP, blood pressure; eGFR, estimated glomerular filtration rate.