FIGURE 6.

BMPER regulates Bcl‐2/Bax ratio and activates Smad3/Akt/Nrf2 signaling pathway. (A) Effects of BMPER on Bcl‐2 and Bax expression in neuron OGD/R model. n = 6. (B) Effects of BMPER on phosphorylated Smad1, Smad2, and Smad3 expression in neuron OGD/R model. n = 3. (C) Effects of BMPER on phosphorylated Akt and Nrf2 expression in neuron OGD/R model. n = 3. Data are expressed as mean ± SEM. **p < 0.01 versus control. ^# p < 0.05, ^## p < 0.01 versus PBS by ANOVA followed by LSD‐t post hoc test. BMP, bone morphogenetic protein; BMPER, BMP‐binding endothelial regulator; OGD/R, oxygen‐glucose deprivation/reperfusion; PBS, phosphate buffered saline