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Scheme of cell behavior during ketogenic diet; (a) normal cell feeding with KD, lower level of glucose prevents glycolysis pathway, increases ketone body level as a result of fatty acid oxidation, thus enhancing level of acetyl-CoA in mitochondria to compensate for the ATP needing (b) cancer cell feeding with KD, and abolishes glycolysis. Additionally, the mitochondria are dysfunctional so the cell cannot produce ATP; thus, KD prevents cancer cell proliferation.
