Figure 7.

Selected micrographs by TEM of renal cells in the STZ group demonstrated active apoptosis with absence of autophagy. Active apoptosis appeared as apoptotic bodies (arrowhead) which are packages of fragmented intracellular components. Cytoplasmic gaps and swollen or irregular mitochondria (M) were abundant. (A) Apoptotic bodies (arrowhead) are mainly the results of splitting of the cellular content into distinct membrane-enclosed vesicles. (B) Apoptotic bodies as the result of plasma membrane blebbing (arrowhead). (C) Empty cytoplasm along with apoptotic bodies of larger size (arrowhead) and in close approximation to the nucleus (N) suggest inclusion of macromolecules such as proteins, lipids, RNA, and DNA.