Figure 2.

Vismodegib suppresses the rate of liver regeneration after PH. (A) Liver-to-body weight ratios of control and vismodegib-treated mice at different times after 70% partial hepatectomy (0, 3 h, 1 day, 2 days, 3 days, 7 days and 10 days), n = 5. (B) Images of mouse livers at 10 days post-PH between the two groups, n = 3. (C) The change in the body weight of the control and vismodegib-treated mice between 3 days pre-PH and 10 days post-PH; the trends of the two groups were consistent, n = 5. (D) Edu was used to analyze the difference in proliferative cell amounts between the normal and vismodegib-treated groups after PH. Representative immunofluorescence results 36 h and 44 h after PH. (E) Quantification percentage of Edu positive cells to DAPI positive cells shown in the histogram. (F) Changes in liver function index of normal mice treated with vismodegib (AST: aspartate aminotransferase, ALT: alanine aminotransferase) at different times (0, 3, 7 days). There was almost no difference between the two groups, n = 5. (G) Changes in liver function index (ALT and AST) of mice at different times post-PH in the two groups, n = 5. All data represent means ± SEM. * p < 0.05, ** p < 0.01 vs. control group.