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Expression of microglia activation markers following treatment with ApoE isoforms. Human immortalized microglia cells (HMC3) were grown in vitro and treated for 24 h with 100 µM cholesterol (control) with or without recombinant ApoE2/3/4 (20 nM). Following treatment, cell lysate was collected and Western blot was used to assess the expression of markers related to disease-associated microglia: (A) TREM2 and (B) Clec7a. N = 3, # p < 0.05 vs. ApoE3.
