Table 3.
Index of ADME properties to predict drug-likeliness of the screened phytochemicals.
| Ligand | Mol. Wt. g/mol |
Rotatable Bonds | H-Bond Acceptors | H-Bond Donors | Log Po/w | GI Absorption |
|---|---|---|---|---|---|---|
| Galantamine | 287.4 | 1 | 4 | 1 | 1.92 | High |
| Sanguinarine | 332.3 | 0 | 4 | 0 | 2.88 | High |
| Huperzine A | 242.3 | 1 | 2 | 2 | 1.88 | High |
| Chelerythrine | 348.4 | 2 | 4 | 0 | 3.02 | High |
| Yohimbine | 354.4 | 2 | 4 | 2 | 2.48 | High |
| Berberine | 336.4 | 2 | 4 | 0 | 2.53 | High |
| Berberastine | 352.4 | 2 | 5 | 1 | 1.72 | High |
| Naringenin | 272.3 | 1 | 5 | 3 | 1.84 | High |
| Akuammicine | 322.4 | 2 | 3 | 1 | 2.60 | High |
| Carvone | 150.2 | 1 | 1 | 0 | 2.44 | High |
| Donepezil | 379.5 | 6 | 4 | 0 | 4.00 | High |
| Huperzine-4C-Naringenin | 552.7 | 7 | 6 | 4 | 3.20 | Low |
| Naringenin-4C- Galantamine |
583.7 | 7 | 8 | 3 | 2.46 | High |
| Huperzine-4C- Galantamine |
569.7 | 7 | 6 | 3 | 3.33 | High |
| Huperzine-5C-Carvone | 459.7 | 8 | 3 | 2 | 4.38 | High |
| Yohimbine-5C-Carvone | 556.8 | 9 | 4 | 3 | 3.53 | High |
| Galantamine-4C- Carvone |
476.6 | 7 | 5 | 1 | 3.43 | High |
| Sanguinarine-4C- Carvone |
522.6 | 6 | 5 | 0 | 4.46 | Low |
| Berberine-4C-Carvone | 525.7 | 8 | 5 | 0 | 3.79 | High |
| Chelerythrine-4C- Carvone |
538.7 | 8 | 5 | 0 | 4.24 | Low |
| Berberastine-4C- Carvone |
541.7 | 8 | 6 | 1 | 2.99 | High |
| Akuammicine-4C- Carvone |
467.3 | 6 | 3 | 0 | 4.50 | High |