Table 4.

Prediction of acute oral and hepatotoxicity of the phytochemicals and designed heterodimers.

Ligand	LD50 Predicted in Rodent (mg/kg)	Toxicity Class *	Hepatotoxicity
Galantamine	85	III	Inactive
Sanguinarine	778	IV	Inactive
Huperzine A	5	II	Inactive
Chelerythrine	778	IV	Inactive
Yohimbine	300	III	Inactive
Berberine	200	III	Inactive
Berberastine	200	III	Inactive
Naringenin	2000	IV	Inactive
Akuammicine	28	II	Inactive
Carvone	1640	IV	Inactive
Donepezil	505	IV	Inactive
Huperzine-4C-Naringenin	280	III	Inactive
Naringenin-4C-Galantamine	100	III	Inactive
Huperzine-4C-Galantamine	100	III	Inactive
Huperzine-5C-Carvone	150	III	Inactive
Yohimbine-5C-Carvone	300	III	Inactive
Galantamine-4C-Carvone	100	III	Inactive
Sanguinarine-4C-Carvone	296	III	Inactive
Berberine-4C-Carvone	200	III	Inactive
Chelerythrine-4C-Carvone	296	III	Inactive
Berberastine-4C-Carvone	1000	IV	Inactive
Akuammicine-4C-Carvone	325	IV	Inactive

* Class I: fatal if swallowed (LD₅₀ ≤ 5). Class II: fatal if swallowed (5 < LD₅₀ ≤ 50). Class III: toxic if swallowed (50 < LD₅₀ ≤ 300). Class IV: harmful if swallowed (300 < LD₅₀ ≤ 2000). Class V: may be harmful if swallowed (2000 < LD₅₀ ≤ 5000), Class VI: non-toxic (LD₅₀ > 5000).