Figure 2.

Effect of multiple paclitaxel (Pacli) injections on the response to cold and mechanical stimuli in mice (A,B). Paclitaxel was administered intraperitoneally on D0, D2, D4, and D6 (2 mg/kg each). Cold and mechanical allodynia were measured by using acetone-drop and von-Frey-filament tests, respectively. Behavioral tests were conducted before (D0) and 10, 15, 17, and 21 days following the initiation of paclitaxel treatment. Control-group mice were injected with a mixture of 50% ethanol and 50% Cremophor EL solution (1:1) as a control of paclitaxel (i.p.). Control: n = 7, Pacli: n = 8. **** p < 0.0001 vs. Control with two-way ANOVA followed by Sidak’s post-test for multiple comparisons.