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. 2022 Jan 31;44(2):718–730. doi: 10.3390/cimb44020050

Figure 3.

Figure 3

Effect of SH003 oral administration on cold and mechanical allodynia induced by multiple paclitaxel injection in mice (A,B). Behavioral measurements were conducted before (baseline) and 1 h after the treatment of SH003 or PBS. Two different doses of SH003 (100 and 500 mg/kg) and PBS were given orally. PBS was used as control to SH003. Control: n = 6, SH003 100 mg/kg: n = 6, SH003 500 mg/kg: n = 7. ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. Control with two-way ANOVA followed by Sidak’s post-test for multiple comparisons.