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. 2022 Jan 31;44(2):718–730. doi: 10.3390/cimb44020050

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of SH003 components on paclitaxel-induced cold and mechanical allodynia (A,B). Behavioral tests were conducted before and 1 h after the oral treatment of Am, As, Tk, DLX and PBS in mice. PBS was administered as a control to Am, Ag, Tk, and DLX. DLX was intraperitoneally injected as a positive control. Am: Astragalus membranaceus, Ag: Angelica gigas, Tk: Trichosanthes kirilowii Maximowicz, DLX: Duloxetine. Control: n = 13, Am 500 mg/kg: n = 6, Ag 500 mg/kg: n = 6, Tk 500 mg/kg: n = 6, DLX 30 mg/kg: n = 6. ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. Baseline with two-way ANOVA followed by Sidak’s post-test for multiple comparisons.