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. 2022 Jan 31;44(2):718–730. doi: 10.3390/cimb44020050

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Analgesic effect of Tk following intrathecal injection of methysergide (A,B) or MDL-72222 (C,D) was assessed on cold (A,C) and mechanical (B,D) allodynia. Methysergide and MDL-72222 are 5-HT_1/2 and 5-HT₃-receptor antagonists, respectively. PBS and 20% DMSO were administered intrathecally as a control to methysergide and MDL-72222, respectively. Pacli: paclitaxel, Tk: Trichosanthes kirilowii Maximowicz. Pacli + PBS + PBS: n = 6, Pacli + PBS + Tk: n = 6, Pacli + methysergide + Tk: n = 6, Pacli + 20%DMSO + PBS: n = 6, Pacli + 20%DMSO + Tk: n = 6, Pacli + MDL-72222 + Tk: n = 6. ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. baseline with two-way ANOVA followed by Sidak’s post-test for multiple comparisons.