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. 2022 Jan 31;44(2):718–730. doi: 10.3390/cimb44020050

Figure 7.

Figure 7

Efficacy of cucurbitacin D (CucD), a component of Tk, on paclitaxel-induced neuropathic pain (A,B). Efficacy of Tk (500 mg/kg) and CucD (0.025 and 0.1 mg/kg) were investigated 1 h after its treatment. 20% DMSO was used as a control of CucD (i.p.). Tk was orally administered as a positive control. CucD: Cucurbitacin D, Tk: Trichosanthes kirilowii Maximowicz. Naive: n = 6, Pacli + 20%DMSO: n = 6, Pacli + Tk: n = 6, Pacli + CucD 0.025 mg/kg: n = 6, Pacli + CucD 0.1 mg/kg: n = 6. *** p < 0.001, **** p < 0.0001 vs. Baseline with two-way ANOVA followed by Sidak’s post-test for multiple comparisons.