Table 1.
Relationship between MC1R expression and clinicopathological characteristics of CRC patients.
| Clinicopathological Characteristics |
Total Patients |
MC1R | p | |
|---|---|---|---|---|
|
MC1R Low Expression Group |
MC1R High Expression Group |
|||
| Total Sex |
86 | 43 | 43 | |
| 0.639 | ||||
| Male | 60 | 31 (51.7%) | 29 (48.3%) | |
| Female | 26 | 12 (46.2%) | 14 (53.8%) | |
| Age | 0.826 | |||
| ≥65 | 35 | 18 (51.4%) | 17 (48.6%) | |
| <65 | 51 | 25 (49.0%) | 26 (51.0%) | |
| Differentiation | 0.655 | |||
| Middle | 54 | 28 (51.9%) | 26 (48.1%) | |
| Poor | 32 | 15 (46.9%) | 17 (53.1%) | |
| T stage | 0.360 | |||
| T1and T2 | 5 | 1 (20.0%) | 4 (80.0%) | |
| T3and T4 | 81 | 42 (51.9%) | 39 (48.1%) | |
| N stage | 0.514 | |||
| N0 | 49 | 26 (53.1%) | 23 (46.9%) | |
| N1, N2 and N3 | 37 | 17 (45.9%) | 20 (54.1%) | |
| M stage | 1.000 | |||
| M0 | 1 | 0 (0.0%) | 1 (100.0%) | |
| M1 | 85 | 43 (50.6%) | 42 (49.4%) | |
| TNM stage | 0.829 | |||
| I and II | 47 | 24 (51.1%) | 23 (48.9%) | |
| III and IV | 39 | 19 (48.7%) | 20 (51.3%) | |
| P53 status | 0.030 * | |||
| ≥70.0% | 38 | 24 (63.2%) | 14 (36.8%) | |
| <70.0% | 48 | 19 (39.6%) | 29 (60.4%) | |
| Ki67 status | 0.079 | |||
| ≥70.0% | 65 | 36 (55.4%) | 29 (44.6%) | |
| <70.0% | 21 | 7 (33.3%) | 14 (66.7%) | |
| MLH1 status | 0.048 * | |||
| ≥70.0% | 64 | 36 (56.3%) | 28 (43.7%) | |
| <70.0% | 22 | 7 (31.8%) | 15 (68.2%) | |
| MSH2 status | 0.213 | |||
| ≥70.0% | 74 | 39 (52.7%) | 35 (47.3%) | |
| <70.0% | 12 | 4 (33.3%) | 8 (66.7%) | |
| MSH6 status | 0.268 | |||
| ≥70.0% | 70 | 37 (52.9%) | 33 (47.1%) | |
| <70.0% | 16 | 6 (37.5%) | 10 (62.5%) | |
| PMS2 status | 0.041 * | |||
| ≥70.0% | 66 | 37 (56.1%) | 29 (43.9%) | |
| <70.0% | 20 | 6 (30.0%) | 14 (70.0%) | |
| MS status | 0.034 * | |||
| MSI | 18 | 5 (27.8%) | 13 (72.2%) | |
| MSS | 68 | 38 (55.9%) | 30 (44.1%) | |
Analysis software: SPSS 25.0 statistical software; analysis method: Chi-square test or Fisher’s exact test. * p < 0.05 was considered significant.