Table 2.
Correlation analysis of MC1R SNPs and clinical factors.
| Clinical Factors |
Total Patients | rs2228479 | p | rs885479 | p | ||
|---|---|---|---|---|---|---|---|
| GG (%) |
GA and AA (%) |
GG (%) |
GA and AA (%) |
||||
| Total | 100 | ||||||
| Sex Male |
70 |
57 (81.4) |
0.772 | 0.274 | |||
| 13 (18.6) | 9 (12.9) | 61 (87.1) | |||||
| Female | 30 | 26 (86.7) | 4 (13.3) | 1 (3.3) | 29 (96.7) | ||
| Age | 0.514 | 0.013 * | |||||
| ≥65 | 40 | 32 (80.0) | 8 (20.0) | 8 (20.0) | 32 (80.0) | ||
| <65 | 60 | 51 (85.0) | 9 (15.0) | 2 (3.3) | 58 (96.7) | ||
| Differentiation | 0.913 | 0.738 | |||||
| Middle | 60 | 50 (83.3) | 10 (16.7) | 6 (10.0) | 54 (90.0) | ||
| Poor | 40 | 33 (82.5) | 7 (17.5) | 3 (7.5) | 37 (92.5) | ||
| T stage | 1.000 | 0.001 * | |||||
| T1and T2 | 6 | 5 (83.3) | 1 (16.7) | 4 (66.7) | 2 (33.3) | ||
| T3 and T4 | 94 | 78 (83.0) | 16 (17.0) | 6 (6.4) | 88 (93.6) | ||
| N stage | 0.661 | 1.000 | |||||
| N0 | 54 | 44 (81.5) | 10 (18.5) | 5 (9.3) | 49 (91.7) | ||
| N1, N2 and N3 |
46 | 39 (84.8) | 7 (15.2) | 5 (10.9) | 41 (90.1) | ||
| TNM stage | 0.661 | 0.506 | |||||
| I and II | 54 | 44 (81.5) | 10 (18.5) | 4 (7.4) | 50 (92.6) | ||
| III and IV | 46 | 39 (84.8) | 7 (15.2) | 6 (13.0) | 40 (87.0) | ||
| Total | 86 | ||||||
| P53 status | 0.913 | 1.000 | |||||
| ≥70.0% | 38 | 32 (84.2) | 6 (15.8) | 3 (7.9) | 35 (92.1) | ||
| <70.0% | 48 | 40 (83.3) | 8 (16.7) | 4 (8.3) | 44 (91.7) | ||
| Ki67 status | 0.004* | 1.000 | |||||
| ≥70.0% | 65 | 59 (90.8) | 6 (9.2) | 5 (7.7) | 60 (92.3) | ||
| <70.0% | 21 | 13 (61.9) | 8 (38.1) | 2 (9.5) | 19 (90.5) | ||
| MLH1 status | 0.336 | 1.000 | |||||
| ≥70.0% | 64 | 55 (85.9) | 9 (14.1) | 5 (7.8) | 59 (92.2) | ||
| <70.0% | 22 | 17 (77.3) | 5 (22.7) | 2 (9.1) | 20 (90.9) | ||
| MSH2 status | 1.000 | 0.251 | |||||
| ≥70.0% | 74 | 62 (83.8) | 12 (16.2) | 5 (6.8) | 69 (93.2) | ||
| <70.0% | 12 | 10 (83.3) | 2 (16.7) | 2 (16.7) | 10 (83.3) | ||
| MSH6 status | 1.000 | 0.610 | |||||
| ≥70.0% | 70 | 58 (82.9) | 12 (17.1) | 5 (7.1) | 65 (92.9) | ||
| <70.0% | 16 | 14 (87.5) | 2 (12.5) | 2 (12.5) | 14 (87.5) | ||
| PMS2 status | 0.299 | 1.000 | |||||
| ≥70.0% | 66 | 57 (86.4) | 9 (13.6) | 6 (9.1) | 60 (90.9) | ||
| <70.0% | 20 | 15 (75.0) | 5 (25.0) | 1 (5.0) | 19 (95.0) | ||
| MS status | 1.000 | 0.633 | |||||
| MSI | 18 | 15 (83.3) | 3 (16.7) | 2 (11.1) | 16 (88.9) | ||
| MSS | 68 | 57 (83.8) | 11 (16.2) | 5 (7.4) | 63 (92.6) | ||
Analysis software: SPSS 25.0 statistical software; analysis method: Chi-square test or Fisher’s exact test. * p < 0.05 was considered significant.