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. 2021 Oct 24;43(3):1741–1755. doi: 10.3390/cimb43030123

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of treatment with Ger (100 and 200 mg/kg) for 19 days on the Keap-1/Nrf2/HO-1 signaling pathway including mRNA expression on (a) Keap-1, (b) Nrf2 and (c) HO-1 levels and on protein expression of (d) Keap-1, (e) Nrf2 and (f) HO-1 levels in MTX-induced AKI in rats (n = 6). All values are expressed as mean ± SD. #, statistically significant from normal group; *, statistically significant from MTX-only group; @, statistically significant from MTX + Ger 100 mg/kg group (p < 0.05) using one-way ANOVA followed by Tukey’s post hoc analysis.