Table 3.
Effects of treatment with geraniol on antioxidants activities in MTX-induced AKI in rats.
| Normal | Ger | MTX (20 mg/kg) | MTX + Ger (100 mg/kg) | MTX + Ger (200 mg/kg) | |
|---|---|---|---|---|---|
| MDA (nmol/100 mg) | 22.60 ± 3.65 | 25.34 ± 5.32 | 92.83 ± 8.37 # | 34.96 ± 5.04 * | 30.64 ± 4.15 * |
| NO (nmol/100 mg) | 21.39 ± 0.30 | 20.76 ± 3.59 | 79.24 ± 0.38 # | 52.46 ± 0.22 * | 32.01 ± 0.18 *,@ |
| Reduced GSH (nmol/100 mg) | 69.56 ± 8.48 | 67.12 ± 13.76 | 22.91 ± 2.12 # | 32.27 ± 3.51 * | 48.97 ± 6.51 *,@ |
| GSHPx (U/g protein) | 0.060 ± 0.01 | 0.062 ± 0.0093 | 0.045 ± 0.02 | 0.051 ± 0.01 * | 0.055 ± 0.02 *,@ |
| SOD (U/g protein) | 292.92 ± 22.43 | 300.32 ± 24.61 | 156.28 ± 0.69 # | 205.33 ± 22.4 * | 253.87 ± 11.31 *,@ |
| CAT (nmol/g tissue) | 76.13 ± 5.34 | 82.23 ± 15.28 | 22.70 ± 0.66 # | 34.80 ± 5.16 * | 48.75 ± 4.38 *,@ |
All values are expressed as mean ± SD, (n = 6). #, statistically significant from normal group; *, statistically significant from MTX-only group; @, statistically significant from MTX + Ger 100 mg/kg group (p < 0.05) using one-way ANOVA followed by Tukey’s post hoc analysis.