Table 3.
Carcinogen and toxic evaluation of yohimbine.
| Parameters | Unit | Yohimbine |
|---|---|---|
| Rat inhalation LC50 | mg/m3/h | 3590.05 |
| Rate of oral LD50 | g/kg body weight | 0.311154 |
| Rat chronic LOEAL | g/kg body weight | 0.00473724 |
| Daphnia EC50 | mg/mL | 4.13671 |
| Fathead minnow LC50 | g/L | 0.0106882 |
| hERG (hERG Blockers) | + | |
| H-HT (Human Hepatotoxicity) | − | |
| DILI (Drug Induced Liver Injury) | − | |
| Carcinogenic potency TD50 | ||
| Rat | mg/kg body weight/day | 0.00302322 |
| Mouse | mg/kg body weight/day | 27.5687 |
| Rat maximum tolerated dose | g/kg body weight | 0.0664294 |
| Developmental toxicity potential | Toxic | |
| Aerobic biodegradability | Non-degradable | |
| Ames mutagenicity | Non-mutagen | |
| Skin irritancy | Mild | |
| Ocular irritancy | Severe |