Table 1.

Evidence supporting a link between aging and/or hypertension and increased CD47 levels.

Reference	Link between Aging and/or Hypertension and Increased CD47 Levels
[33]	CD47 downregulation may be involved in the alpha-tocopherol-mediated inhibition of age-associated streptococcus pneumoniae lung infection in mice
[37]	Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia
[38]	CD47 null mice indicate that CD47 functions as a vasopressor
[39]	CD47-null mice are leaner—loss of signaling from the TSP1-CD47 system promotes the accumulation of normally functioning mitochondria in a tissue-specific and age-dependent fashion, leading to enhanced physical performance, lower reactive oxygen species production, and more efficient metabolism
[40]	High CD47 levels promote pulmonary arterial hypertension in the lungs from humans and mice
[41]	TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction
[42]	Increased THBS1/CD47 signaling contributes to reduced skin blood flow and wound healing in aged mice
[43]	CD47 blocks NO-mediated vasodilatation
[44]	THBS1/CD47 signaling drives endothelial cell senescence
[45]	TSP1 promotes ageing-associated human and mouse endothelial cell senescence through CD47
[46]	Increased CD47 expression causes age-associated deterioration in angiogenesis, blood flow, and glucose homeostasis
[47]	Increased CD47 levels in the lung of a sickle cell disease patient with pulmonary arterial hypertension relative to control tissues
[48]	Pulmonary hypertension reduced in a CD47-null mouse model of sickle cell disease
[49]	Anti-CD47 antibodies reversed fibrosis in various organs in mouse models