Table 2.

Evidence supporting a link between diabetes and increased CD47 levels.

Reference	Link between Aging and/ or Hypertension and Increased CD47 Levels
[58]	Hyperglycemia protects CD47 from cleavage
[59]	Hyperglycemia protects CD47 from cleavage
[60]	Hyperglycemia protects CD47 from cleavage
[61]	Hyperglycemia protects CD47 from cleavage
[62]	CD47 is involved in pathophysiological changes in retinal cells in response to hyperglycemia in cell cultures and rats
[63]	Elevated CD47 mRNA levels both in the hippocampus and prefrontal cortex of a type-2 diabetes rat model
[64]	Increased levels of CD47 in epiretinal membranes with active neovascularization in proliferative diabetic retinopathy
[65]	Increased THBS1/CD47 signaling in bone marrow-derived angiogenic cells in a rat diabetes model
[66]	Increased diabetes-associated CD47 levels inhibit angiogenesis and wound healing in a diabetes model in rats