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. 2021 Oct 3;43(3):1419–1435. doi: 10.3390/cimb43030100

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Diagnostic value of cfDNA yield. Statistical comparison of the isolated amount of cfDNA from CRC and control non-tumour samples (CNT) provided evidence that the amount of isolated cfDNA is a strong indicator for the presence of a tumour. (A): Increased amounts of cfDNA (4.36 +/− 4.82 ng DNA/mL plasma) were found in CRC compared to CNT (2.06 +/− 1.27 ng DNA/mL plasma), which are statistically significant (p = 2 × 10−5). (B): single AUC value was 0.73. (C): Heatmap with hierarchical clustering for CRC and CNT samples. Two major clusters with prevalence for either CRC or CNT are present. However, 8 CNT and 5 CRC samples did not cluster to the correct group, maybe indicating samples with an intermediate state.