Table 3.
Differential DNA methylation was detected in 20 of the 44 targets in early CRC patients, which enables early identification of CRC. All the targets were found to be hypermethylated in CRC.
| Gene Symbol | p-Value | Mean of | Mean of | Fold Change | Entrez ID |
|---|---|---|---|---|---|
| dcp in Control no Tumor (CNT) | dcp in CRC | ||||
| PITX2 | 1.00 × 10−7 | 8.03 | 7.3 | 1.66 | paired-like homeodomain 2 |
| DCC | 2.00 × 10−7 | 7.89 | 7.26 | 1.55 | DCC netrin 1 receptor |
| TMEFF2 | 4.00 × 10−7 | 6.23 | 5.7 | 1.44 | transmembrane protein with EGF-like and two follistatin-like domains 2 |
| TWIST1 | 1.17 × 10−5 | 5.59 | 5.21 | 1.30 | twist family bHLH transcription factor 1 |
| MYOD1 | 4.68 × 10−5 | 6.53 | 6.08 | 1.37 | myogenic differentiation 1 |
| SPARC | 3.35 × 10−4 | 6.24 | 5.75 | 1.40 | secreted protein, acidic, cysteine-rich (osteonectin) |
| TP53 | 6.01 × 10−4 | 6.46 | 6.08 | 1.30 | tumor protein p53 |
| WT1 | 1.07 × 10−3 | 6.62 | 5.47 | 2.22 | Wilms tumor 1 |
| CXADR | 1.23 × 10−3 | 4.71 | 4.53 | 1.13 | coxsackie virus and adenovirus receptor |
| SERPINB2 | 1.27 × 10−3 | 5.32 | 5.4 | 0.95 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| S100A2 | 1.68 × 10−3 | 5.9 | 5.65 | 1.19 | S100 calcium binding protein A2 |
| SRGN | 4.82 × 10−3 | 3.85 | 3.79 | 1.04 | serglycin |
| PITX2 | 5.97 × 10−3 | 6.38 | 5.93 | 1.37 | paired-like homeodomain 2 |
| PENK | 8.63 × 10−3 | 8.41 | 7.33 | 2.11 | proenkephalin |
| CDX1 | 1.41 × 10−2 | 5.85 | 5.67 | 1.13 | caudal type homeobox 1 |
| BOLL | 2.42 × 10−2 | 6.41 | 6.06 | 1.27 | boule-like RNA-binding protein |
| NKX2-1 | 2.97 × 10−2 | 6.7 | 6.3 | 1.32 | NK2 homeobox 1 |
| TFPI2 | 3.13 × 10−2 | 7.75 | 7.24 | 1.42 | tissue factor pathway inhibitor 2 |
| DAPK1 | 3.32 × 10−2 | 9.39 | 6.95 | 5.43 | death-associated protein kinase 1 |
| THBD | 3.81 × 10−2 | 7.88 | 6.5 | 2.60 | thrombomodulin |