Table 5.
Overview of the 26 targets found with differential methylation of patients with CRC liver metastasis, responding/non-responding to neoadjuvant chemotherapy.
| Time Point 1 | Time Point 2 | Time Point 3 | ||||
|---|---|---|---|---|---|---|
| p-Value | Fold-Change | p-Value | Fold-Change | p-Value | Fold-Change | |
| TWIST1 | 4.26 × 10−3 | 2.78 | ||||
| CDX1 | 6.12 × 10−3 | 12.7 | 1.84 × 10−3 | 18.3 | 2.77 × 10−2 | 6.63 |
| PITX2 | 7.40 × 10−3 | 6.67 | 1.91 × 10−2 | 13.4 | 1.64 × 10−2 | 2.5 |
| ESR1 | 1.55 × 10−2 | 3.23 | ||||
| CD24 | 1.59 × 10−2 | <1 × 10−7 | 4.86 × 10−2 | 547 | ||
| BOLL | 1.61 × 10−2 | 4 | ||||
| PTGS2 | 1.62 × 10−2 | 313 | ||||
| MYOD1 | 2.15 × 10−2 | 2.44 | ||||
| TBP | 2.67 × 10−2 | 11.6 | 3.40 × 10−4 | 27.9 | 1.05 × 10−3 | 24.3 |
| WT1 | 3.30 × 10−2 | 3.85 | 4.47 × 10−2 | 2.38 | ||
| TMEFF2 | 3.94 × 10−2 | 2.17 | ||||
| SERPINB2 | 3.96 × 10−2 | 125 | 2.50 × 10−2 | 667 | ||
| HLA-G | 4.36 × 10−2 | 1.92 | ||||
| SFRP2 | 1.81 × 10−4 | 333 | ||||
| S1000A2 | 3.51 × 10−4 | 15.6 | 3.69 × 10−3 | 7.47 | ||
| TP53 | 2.34 × 10−3 | 21.3 | 4.87 × 10−3 | 26.8 | ||
| THBD | 4.77 × 10−3 | 263 | ||||
| FMR1 | 5.70 × 10−3 | 27,000 | 1.08 × 10−3 | 168,000 | ||
| TCEB2 | 1.39 × 10−2 | 32.6 | ||||
| TFPI2 | 2.17 × 10−2 | 9.09 | ||||
| MSH4 | 2.68 × 10−2 | 2 | ||||
| CALCA | 2.68 × 10− | 2.33 | ||||
| H19 | 2.77 × 10−2 | 1.6 | ||||
| SPARC | 4.28 × 10−2 | 10 | ||||
| IL1B | 4.47 × 10−2 | 1.52 | 8.81 × 10−3 | 2.27 | ||
| RARB | 4.72 × 10−2 | 159 | ||||