TABLE 3.
Effect of osmolarity on MICs of D2A21 in NB for multidrug-resistant pathogens from patients with CF
| Isolatea | MIC (μg/ml) of D2A21 in NB at the following osmolarity:
|
||
|---|---|---|---|
| 56 mosM | 290 mosM | 405 mosM | |
| ATCC 27853 | 4 | 4 | 4 |
| PAE-2 | 2 | ≤1 | ≤1 |
| PAE-5 | 2 | 2 | 2 |
| PAE-7 | ≤1 | ≤1 | ≤1 |
| PAE-8 | 4 | 4 | 4 |
| PAE-9 | 4 | 2 | 2 |
| PAE-10 | ≤1 | ≤1 | ≤1 |
| PAE-11 | ≤1 | ≤1 | ≤1 |
| PAE-12 | ≤1 | ≤1 | ≤1 |
| PAE-26 | 4 | 2 | 4 |
| PAE-30 | ≤1 | ≤1 | ≤1 |
| ATCC 29213 | 8 | 4 | 64 |
| MRSA-1 | 2 | 2 | 4 |
| MRSA-2 | 4 | 4 | 8 |
| MRSA-4 | 4 | 8 | 8 |
| MRSA-5 | 4 | 8 | 8 |
| MRSA-6 | 4 | 8 | 16 |
| MRSA-23 | 4 | 4 | 16 |
| MRSA-24 | 2 | 4 | 4 |
| MRSA-29 | 2 | 4 | 4 |
| MRSA-32 | 4 | 4 | 8 |
| MRSA-33 | 4 | 4 | 8 |
| SM-1 | 4 | 2 | 4 |
| SM-4 | ≤1 | ≤1 | ≤1 |
| SM-6 | 16 | 16 | 16 |
| SM-12 | 8 | 16 | 16 |
| SM-16 | 8 | 16 | 16 |
| BC-1 | 16 | 32 | 16 |
| BC-8 | ≥64 | ≥64 | ≥64 |
| BC-10 | ≥64 | ≥64 | ≥64 |
| BC-11 | ≥64 | ≥64 | ≥64 |
| BC-12 | ≥64 | ≥64 | ≥64 |
a
PAE, P. aeruginosa; SM, S. maltophilia; BC, B. cepacia.