FIGURE 2.

SARS‐CoV‐2 repeated self‐assembly using thermodynamic spontaneity. The repeated self‐assembly of SARS‐CoV‐2 is driven by Gibbs free energy (GFE), and it is this useable energy that predicts spontaneous change. Shown is the relationship between the dissociation constant (K_d) and the change in GFE of dissociation. ⁷ The negative GFE for binding of SARS‐CoV‐2 to ACE2 is illustrated. The GFE of the growth of the nucleocapsids for SARS‐CoV‐2 is more negative than that of the host tissue. ¹² Illustrated is the view that populations provide the platform to facilitate the repeated self‐assembly at scale of SARS‐CoV‐2. (ΔGd—GFE of dissociation, ΔG—Change in GFE, ΔH—change in enthalpy, ΔS—change in entropy, Kd—dissociation constant, R—ideal gas constant, T—absolute temperature, cθ = 1 mol/L)