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Epidemiological characteristics of the COVID‐19 pandemic reflect repeated SARS‐CoV‐2 target binding at enormous scale. Illustrates how entropy considerations predict outcomes not only at a cellular level but across infected populations reflecting the enormity of the repetition scale of thermodynamic spontaneity associated with the high affinity of SARS‐CoV‐2 for the ACE2 target in single cells, in multiple cells, in organs and tissues and across multiple cells in populations
