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. 2022 Mar 3;13:730186. doi: 10.3389/fimmu.2022.730186

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Copyright © 2022 Liu, Gu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of inflammation response and hypoxia-related gene signature. (A) Cluster dendrogram and co-expression modules were identified using Weighted Gene Co-expression Network Analysis. Each colour represents one module. (B) Correlation analysis between the gene module and inflammatory response and hypoxia-related gene signature. (C) The prognosis-related genes in the green-yellow and light-green modules were screened using univariate Cox regression. (D) The top 10 genes were identified using random survival forest algorithms. (E) The top 20 gene signatures were ranked by -log10 p-value on a Kaplan–Meier plotter.